A-381393
A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM) [1].
Product Specifications
CAS Number
726174-00-1
Product Name Alternative
Bisdesethylchloroquine,Bisdesethylchloroquine-d13
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/A-381393.html
Purity
99.92
Solubility
DMSO : 51.67 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3
Molecular Formula
C20H24N4
Molecular Weight
320.43
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; D3 Receptor; D4 Receptor
Available Sizes
Frequently Asked Questions
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