HVH-2930
HVH-2930 is an inhibitor for heat shock protein 90 (HSP90) . HVH-2930 inhibits cell viability of BT474 (Trastuzumab (HY-P9907) sensitive) and JIMT-1 (Trastuzumab (HY-P9907) resistant), with IC50 of 6.86 μM and 4.42 μM, through downregulation of HSP90 clients HER2, p-HER2, AKT, p-AKT, cyclin D1 and survivin. HVH-2930 exhibits antitumor efficacy in mouse models. HVH-2930 exhibits good pharmacokinetic characteristics in mice[1].
Product Specifications
CAS Number
[3034605-72-3]
UNSPSC
12352005
Target
Akt; EGFR; HSP; Survivin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hvh-2930.html
Purity
96.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(OC)C(C=CC(C)(C)O2)=C2C=C1)NC3=CC4=C(C=C3)C(C)=NN4CCC5CCN(C)CC5
Molecular Formula
C29H36N4O3
Molecular Weight
488.62
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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