Kira8
Product Specifications
Product Name Alternative
meta-MDL-16455; meta-Terfenadine carboxylate
UNSPSC Description
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].
Target Antigen
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Kira8.html
Purity
98.60
Solubility
DMSO : 65 mg/mL (ultrasonic)|Ethanol : 76.92 mg/mL (ultrasonic;adjust pH to 5 with HCl)|H2O : 30 mg/mL (ultrasonic;warming;adjust pH to 2 with HCl;heat to 60°C)
Smiles
O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[C@@H]6CNCCC6)=NC=C5)C3=CC=C2)=O
Molecular Weight
601.12
References & Citations
[1]Morita S, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25(4):883-897.e8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114368/Kira8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114368/Kira8-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1630086-20-2
Available Sizes
Curated Selection
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