AHR antagonist 8
AHR antagonist 8 (compound SG-02) is a regulator of utrophin, a homolog of dystrophin, and an AhR antagonist (Kd: 41.68 nM) . Studies have shown that 800 nM of AHR antagonist 8 can upregulate utrophin by 2.7 times. AHR antagonist 8 also stimulates increased MyHC expression, suggesting that it has the potential to enhance myogenesis. After ADME evaluation, AHR antagonist 8 also has a certain oral bioavailability[1].
Product Specifications
UNSPSC
12352005
Target
Aryl Hydrocarbon Receptor; Dystrophin
Type
Reference compound
Related Pathways
Cytoskeleton; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ahr-antagonist-8.html
Smiles
O=S(C1=CC2=CN=C(NCC3=CC=C(F)C=C3)N=C2C=C1)(C)=O
Molecular Formula
C16H14FN3O2S
Molecular Weight
331.36
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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