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Arotinoid

Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED50 of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas[1][2].

Product Specifications

CAS Number

71441-09-3

Product Name Alternative

Ro 13-6298; Arotinoid ethyl ester

UNSPSC

12352005

Target

RAR/RXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/arotinoid.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1(C2=CC(/C(C)=C/C3=CC=C(C(OCC)=O)C=C3)=CC=C2C(C)(C)CC1)C

Molecular Formula

C26H32O2

Molecular Weight

376.53

References & Citations

[1]Tsambaos D, Orfanos CE. Antipsoriatic activity of a new synthetic retinoid. The arotinoid RO 13-6298. Arch Dermatol. 1983 Sep;119 (9) :746-51.|[2]Bollag W. Arotinoids. A new class of retinoids with activities in oncology and dermatology. Cancer Chemother Pharmacol. 1981;7 (1) :27-9.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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