COP1-ATGL modulator 1

COP1-ATGL modulator 1 (86) is an orally active modulator for COP1-ATGL axis. COP1-ATGL modulator 1 (86) could increase ATGL protein expression, reduce ATGL ubiquitination and COP1 autoubiquitination, and diminish lipid accumulation in hepatocytes in the nanomolar range[1].

Product Specifications

CAS Number

[2946701-09-1]

UNSPSC

12352005

Target

ATGL; E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cop1-atgl-modulator-1.html

Concentration

10mM

Purity

99.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C(C2=CC(NC(NC3=CC(C(C)=O)=CC=C3)=O)=CC=C2N1CCN4CCCCC4)=O)CCOC

Molecular Formula

C27H33N5O5

Molecular Weight

507.58

References & Citations

[1]Dipayan Sarkar, et al. Discovery and Development of Quinazolinones and Quinazolinediones for Ameliorating Nonalcoholic Fatty Liver Disease (NAFLD) by Modulating COP1-ATGL Axis. J Med Chem. 2023 Dec 28;66 (24) :16728-16761.