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Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide

Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Desthiobiotin-PEG3-triazole-DBCO-sulfo-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups[1].

Product Specifications

UNSPSC

12352200

Target

ADC Linker

Type

Biochemical Assay Reagents

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/desthiobiotin-peg3-triazole-dbco-sulfo-maleimide.html

Smiles

C[C@@H]1NC(N[C@@H]1CCCCCC(NCCOCCOCCOCCN2N=NC3=C2C4=C(N(CC5=C3C=CC=C5)C(CCNC(C(S(=O)(O)=O)CNC(CCN6C(C=CC6=O)=O)=O)=O)=O)C=CC=C4)=O)=O

Molecular Formula

C46H60N10O13S

Molecular Weight

993.09

References & Citations

[1]Portnoff AD, et al. An antidote approach to reduce risk and broaden utility of antibody-based therapeutics. J Biol Chem. 2017 May 19;292 (20) :8498-8506.

Shipping Conditions

Room temperature

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Frequently Asked Questions

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