Acetyl-Hirudin (54-65) (sulfated)

Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII (L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex[1].

Product Specifications

CAS Number

[125441-00-1]

UNSPSC

12352209

Target

Thrombin

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/acetyl-hirudin-54-65-sulfated.html

Solubility

H2O

Smiles

CC(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N2[C@@H](CCC2)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)CC3=CC=C(C=C3)OS(=O)(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C68H95N13O29S

Molecular Weight

1590.62

References & Citations

[1]J H Han, et al. Heparin facilitates dissociation of complexes between thrombin and a reactive site mutant (L444R) of heparin cofactor II. J Biol Chem. 1997 Mar 28;272 (13) :8243-9.