SC-58272
SC-58272 is a potent and selective dipeptide N-myristoyltransferase (Nmt) inhibitor with an IC50 of 56 nM for C. albicans (strain B311) Nmt. SC-58272 shows 250-fold selective for the fungal enzyme compared to human enzyme[1].
Product Specifications
CAS Number
164931-25-3
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sc-58272.html
Smiles
O=C(NCCC1CCCCC1)[C@H](CCCCN)NC([C@H](CO)NC(CC2=CC=C(C=C2)CCCCN3C(C)=NC=C3)=O)=O
Molecular Formula
C33H52N6O4
Molecular Weight
596.80
References & Citations
[1]Jennifer K Lodge, et al. N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase. Microbiology (Reading) . 1997 Feb:143 (Pt 2) :357-366.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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