URAT1/GLUT9-IN-1

URAT1/GLUT9-IN-1 (compound 29) can inhibit both uric acid transporter 1 (URAT1) (IC50=2.01 μM) and glucose transporter 9 (GLUT9) (IC50=18.21 μM) . URAT1/GLUT9-IN-1 exhibits favorable pharmacokinetic properties and oral bioavailability. URAT1/GLUT9-IN-1 can be uesd for gout and hyperuricemia research[1].

Product Specifications

CAS Number

[2883011-18-3]

UNSPSC

12352005

Target

GLUT; URAT1

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/urat1-glut9-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CCCSC1=NC(NC2=C3C=CC=CC3=C(C4CC4)C=C2)=C5C(C=CS5)=N1

Molecular Formula

C23H21N3O2S2

Molecular Weight

435.56

References & Citations

[1]Shi X, et al. Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability[J]. Journal of Medicinal Chemistry, 2024, 67 (6) : 5032-5052.