LNX1
Product Specifications
Background
LNX1 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65
Synonyms
Numb-Binding Protein 1, Ligand of Numb-Protein X 1
UniProt
Q8TBB1
Host
Rabbit
Species Reactivity
Human
Conjugation
Unconjugated
Type
Blocking Peptide
Applications
WB
Assay Principle
For use with LNX1 polyclonal antibodies (Cat. No. X2316P , X2340P).
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Armbruester, V., et al. 'Np9 protein of Human endogenous retrovirus K interacts with ligand of numb protein X.; J. Virol. 78:10310-10319(2004).
2. Sollerbrant, K., et al. 'The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).; J. Biol. Chem. 278:7439-7444(2003).
3. Xie, Y., et al. 'Identification of a Human LNX protein containing multiple PDZ domains.; Biochem. Genet. 39:117-126(2001).
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
Curated Selection
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