(S) -Desmethylcitalopram

(S) -Desmethylcitalopram is the isomer of Desmethylcitalopram hydrochloride (HY-113739) . Desmethylcitalopram (DCIT) hydrochloride is the active metabolite of Citalopram (HY-121203) . Desmethylcitalopram has antidepressant effects. Desmethylcitalopram also inhibits cytochrome P450-2D6, -2C19 with IC50s of 39.5 and 53.5 μM[1].

Product Specifications

CAS Number

[144025-14-9]

Product Name Alternative

(S) -DCIT

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H370

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-desmethylcitalopram.html

Smiles

N#CC1=CC2=C([C@](CCCNC)(C3=CC=C(F)C=C3)OC2)C=C1

Molecular Formula

C19H19FN2O

Molecular Weight

310.37

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]von Moltke LL, et aI. Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects. Biol Psychiatry. 1999 Sep 15;46 (6) :839-49.