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JWZ-5-13

JWZ-5-13 is a potent CDK7 PROTAC degrader that significantly degrades CDK7 via the ubiquitin-proteasome system. JWZ-5-13 has antitumor activity. (Pink: Target protein ligand (HY-161830) ; Black: linker (HY-Y0925) ; Blue: E3 ligase ligand (HY-112078) ) [1].

Product Specifications

CAS Number

[3103763-70-5]

UNSPSC

12352005

Target

CDK; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jwz-5-13.html

Purity

98.19

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=NNC2=C1CN(C(N[C@@H](C3=CC=CC=C3)CN(C)C)=O)C2(C)C)C4=CC=C(C#CCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)C=C4

Molecular Formula

C54H66N10O6S

Molecular Weight

983.23

References & Citations

[1]Ji W, et al. Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7) . Eur J Med Chem. 2024 Jun 27;276:116613.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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