Dipotassium glycyrrhizinate (Standard)

Dipotassium glycyrrhizinate (Standard) is the analytical standard of Dipotassium glycyrrhizinate. This product is intended for research and analytical applications. Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity[1][2][3].

Product Specifications

CAS Number

[68797-35-3]

Product Name Alternative

Glycyrrhizic acid (dipotassium) (Standard) ; Dipotassium glycyrrhizate (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reference Standards; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dipotassium-glycyrrhizinate-standard.html

Purity

98.48

Smiles

C[C@]12[C@@](C(C=C3[C@]2(CC[C@]4(C)[C@@]3([H])C[C@](C(O[K])=O)(C)CC4)C)=O)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O6)O)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(O[K])=O)CC5)C)([H])CC1)C

Molecular Formula

C42H60K2O16

Molecular Weight

899.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee SH, et al. Ameliorating effect of dipotassium glycyrrhizinate on an IL-4- and IL-13-induced atopic dermatitis-like skin-equivalent model. Arch Dermatol Res. 2019 Mar;311 (2) :131-140.|[2]Wang LY, et al. Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats. Biomed Pharmacother. 2017 Nov;95:599-604. |[3]Li C, et al. Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling. Thyroid. 2017 May;27 (5) :722-731.|[4]Xu Z, et al. Autophagic degradation of CCN2 (cellular communication network factor 2) causes cardiotoxicity of sunitinib. Autophagy. 2022 May;18 (5) :1152-1173.|[5]Gao L, et al. Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats. Front Pharmacol. 2015 Oct 1;6:215.