ABT-418 (hydrochloride)
ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].
Product Specifications
CAS Number
147388-83-8
UNSPSC
12352005
Hazard Statement
H300+H310+H330
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abt-418-hydrochloride.html
Purity
99.37
Solubility
H2O : 11.9 mg/mL (ultrasonic)
Smiles
CN1[C@H](C2=CC(C)=NO2)CCC1.Cl
Molecular Formula
C9H15ClN2O
Molecular Weight
202.68
Precautions
H300+H310+H330
References & Citations
[1]Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271 (1) :353-61.|[2]Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528 (1) :11-5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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