ABT-418 (hydrochloride)

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].

Product Specifications

CAS Number

[147388-83-8]

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/abt-418-hydrochloride.html

Purity

99.37

Solubility

H2O : 11.9 mg/mL (ultrasonic)

Smiles

CN1[C@H](C2=CC(C)=NO2)CCC1.Cl

Molecular Formula

C9H15ClN2O

Molecular Weight

202.68

Precautions

H300+H310+H330

References & Citations

[1]Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271 (1) :353-61.|[2]Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528 (1) :11-5.