Antitumor agent-145
Antitumor agent-145 (Compound Ir5) is a tumor inhibitor with remarkable fluorescence and mitochondrial targeting, which exerts anti-cancer effects by inducing necroptosis and activating the necroptosis-related immune response[1].
Product Specifications
CAS Number
2983120-65-4
UNSPSC
12352005
Target
Necroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-145.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C2=CC=CC=C2C=C1)/C=[N]3N=C(N(C)C)[S-][Ir+3]\345([N]6=C(C7=C(C=C6)C=CC=C7)C8=CC=CC=[C-]85)[N]9=C(C%10=C(C=C9)C=CC=C%10)C%11=CC=CC=[C-]%114
Molecular Formula
C44H34IrN5OS
Molecular Weight
873.06
References & Citations
[1]Li, Wenjuan et al. “Designing a Mitochondria-Targeted Theranostic Cyclometalated Iridium (III) Complex: Overcoming Cisplatin Resistance and Inhibiting Tumor Metastasis through Necroptosis and Immune Response.” Journal of medicinal chemistry vol. 67,5 (2024) : 3843-3859.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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