2-PPA

2-PPA is a selective inhibitor of TMEM175 (IC50=32 μM) with activity in modulating lysosomal function. Acute inhibition of TMEM175 by 2-PPA increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. 2-PPA can be used in the study of Parkinson's disease[1].

Product Specifications

CAS Number

[21203-86-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-ppa.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL

Smiles

NC1=CC(C2=CC=CC=C2)=NC=C1

Molecular Formula

C11H10N2

Molecular Weight

170.22

Precautions

H302, H315, H319, H335

References & Citations

[1]SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024) .