2-PPA
Product Specifications
UNSPSC Description
2-PPA is a selective inhibitor of TMEM175 (IC50=32 μM) with activity in modulating lysosomal function. Acute inhibition of TMEM175 by 2-PPA increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. 2-PPA can be used in the study of Parkinson's disease[1].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2-ppa.html
Purity
98.18
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1=CC(C2=CC=CC=C2)=NC=C1
Molecular Weight
170.215
References & Citations
[1]SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024).
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-33878/2-PPA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-33878/2-PPA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
21203-86-1
Available Sizes
Curated Selection
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