Sitafloxacin (hydrate)

Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections[1][2][3][4].

Product Specifications

CAS Number

[163253-35-8]

Product Name Alternative

DU6859a (hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Sitafloxacin-hydrate.html

Purity

99.89

Solubility

DMSO : 8.9 mg/mL (ultrasonic; warming) |H2O : < 0.1 mg/mL

Smiles

N[C@H]1C2(CC2)CN(C(C(Cl)=C3N([C@H]4[C@@H](F)C4)C=C(C(O)=O)C5=O)=C(C=C35)F)C1.[1.5H2O]

Molecular Formula

C19H18ClF2N3O3.3/2H2O

Molecular Weight

436.84

Precautions

H302, H315, H319, H335

References & Citations

[1]Anderson, D.L., Sitafloxacin hydrate for bacterial infections. Drugs Today (Barc), 2008. 44 (7) : p. 489-501.|[2]Surapee Tiengrim, et al. Comparative in vitro activity of sitafloxacin against bacteria isolated from Thai patients with urinary tract infections and lower respiratory tract infections. J Med Assoc Thai. 2012 Feb;95 Suppl 2:S6-17.|[3]Keating, et al. Sitafloxacin: in bacterial infections. Drugs, 2011. 71 (6) : p. 731-44.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Quinolone

Citation 01

BioRxiv. 2024 Nov 06.|Antimicrob Resist Infect Control. 2019 Feb 15:8:40.|Curr Microbiol. 2021 Dec 14;79 (1) :12.|Infect Drug Resist. 2019 Jan 31:12:345-358.|PLoS One. 2019 Mar 27;14 (3) :e0213868.