DDR1-IN-9
DDR1-IN-9 is a selective inhibitor of DDR1 with significant kinase activity suppression, exhibiting a Kd value of 4.7 nM and an IC50 value of 9.4 nM. DDR1-IN-9 demonstrates reduced potency against a diverse panel of 400 nonmutated kinases, indicating its specificity. Additionally, DDR1-IN-9 shows favorable pharmacokinetic properties and potential therapeutic effects in a model of pulmonary fibrosis.
Product Specifications
CAS Number
1934246-20-4
UNSPSC
12352005
Target
Discoidin Domain Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ddr1-in-9.html
Purity
99.64
Smiles
C[C@H]1C2=CC=C(C(NC3=CC(N4C=NC(C)=C4)=CC(C(F)(F)F)=C3)=O)C=C2CN(C5=CN=CN=C5)C1
Molecular Formula
C26H23F3N6O
Molecular Weight
492.50
References & Citations
[1]Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![Eph receptor B3 (EPHB3) Mouse Monoclonal Antibody [Clone ID: 4A122D1]](https://cdn.genprice.uk/products/937/68dd189a061270361e8fbcf6/imageurl/am06222su-n.webp)
Eph receptor B3 (EPHB3) Mouse Monoclonal Antibody [Clone ID: 4A122D1]
![Human CD200 Recombinant Rabbit Monoclonal Antibody [PSH05-59] - BSA and Azide free (Capture)](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea81fec/imageurl/ha722379.webp)