Antitumor agent-182
Product Specifications
UNSPSC Description
Antitumor agent-182 (Compound 12a) decreases mitochondrial membrane potential (MMP) and enhances ROS levels. Antitumor agent-182 arrests the cell cycle at G0/G1 phase, induces apoptosis in HeLa. Antitumor agent-182 inhibits the proliferation of HeLa, PC-3 and HCT-15 with IC50s of 8.83, 10.07 and 7.84 μM, respectively[1].
Target Antigen
Apoptosis; Reactive Oxygen Species
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-182.html
Smiles
O=C(OCCCCSC1=NC(C2=CC=C(Cl)C=C2)=CS1)C[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]
Molecular Weight
683.06
References & Citations
[1]Hu Y, et al., Synthesis and anti-proliferative effect of novel 4-Aryl-1, 3-Thiazole-TPP conjugates via mitochondrial uncoupling process. Bioorg Chem. 2024 Sep;150:107588.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159149/Antitumor-agent-182-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159149/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1195299-01 0.02 mg (E-Coli)
Recombinant Campylobacter jejuni subsp.jejuni serotype O:6 Trigger factor (tig)
Ask
View Details MBS1195299-02 0.02 mg (Yeast)
Recombinant Campylobacter jejuni subsp.jejuni serotype O:6 Trigger factor (tig)
Ask
View Details