Verubecestat (tosylate)
Verubecestat tosylate is an orally active, high-affinity BACE1 and BACE2 inhibitor with Ki values of 2.2 nM and 0.38 nM. Verubecestat tosylate effectively reduces Aβ40 and has the potential for Alzheimer's Disease[1][2].
Product Specifications
CAS Number
1875153-95-9
Product Name Alternative
MK-8931 (tosylate)
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/verubecestat-tosylate.html
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.C[C@]2(CS(=O)(N(C(N)=N2)C)=O)C3=CC(NC(C4=CC=C(C=N4)F)=O)=CC=C3F
Molecular Formula
C24H25F2N5O6S2
Molecular Weight
581.61
References & Citations
[1]Yan R, et al. Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs. Transl Neurodegener. 2016 Jul 14;5:13.|[2]Scott JD, et al. Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931) -A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer'sDisease. Med Chem. 2016 Dec 8;59 (23) :10435-10450.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Frequently Asked Questions
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