Rabbit polyclonal antibodies to Insulin Receptor
INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.
Product Specifications
UniProt
P06213
Reactivity
Human
Cross Reactivity
May cross-react with other species
Immunogen
Peptide conjugated to KLH (GGKKNGRILTLPRSNPS)
Target
Insulin receptor (1011-1382 of P06213)
Clonality
Polyclonal
Conjugation
Unconjugated
Field of Research
Metabolism Research
Purification
Immunogen affinity column
Concentration
Batch dependent within range 2.0-2.5 mg/mL
Dilution
Western blot: 0.1-1.0 μg/ml
Form
Liquid
Molecular Weight
42 226 Da
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ELISA, WB
NCBI Accession Number
NP_000199.2
Host or Source
Rabbit
Preservative
Glycine pH 7.2
Isotype
IgG/IgM
Available Sizes
Frequently Asked Questions
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