Rabbit polyclonal antibodies to Bovine S100
Small calcium binding protein that plays important roles in several biological processes such as Ca2+ homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca2+ cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca2+-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca2+ dissociation and myofilament mechanics in order to improve relaxation during diastole
Product Specifications
UniProt
P02638, P02639
Reactivity
Bovine, Human
Cross Reactivity
May cross-react with other species
Immunogen
Native source protein
Target
S100 protein
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Protein A affinity column
Concentration
Batch dependent within range 2.0-2.5 mg/mL
Dilution
Western blot: 0.1-1.0 μg/ml
Form
Liquid
Molecular Weight
10668 (beta), 10518 (alpha)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ELISA, WB
NCBI Accession Number
NP_001029727.1, NP_001092512.1
Host or Source
Rabbit
Preservative
Glycine pH 7.2
Isotype
IgG/IgM
Available Sizes
Frequently Asked Questions
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