CDK-TCIP1
CDK-TCIP1 is a bivalent molecule linking CDK9 inhibitor SNS-032 (HY-10008) to BCL6 ligand BI3812 (HY-111381) . CDK-TCIP1 potently and specifically kills BCL6-overexpressing cells with EC50 of 7.7 nM for SUDHL5 cells[1].
Product Specifications
CAS Number
[3008612-35-6]
UNSPSC
12352005
Target
Bcl-2 Family; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-tcip1.html
Purity
98.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C1=CN=C(CSC2=CN=C(NC(C3CCN(C(CCCCCCNC(C(CC4)CCN4C5=NC=C(Cl)C(NC6=CC(C=C(OCC(NC)=O)C(N7C)=O)=C7C(OC)=C6)=N5)=O)=O)CC3)=O)S2)O1)C
Molecular Formula
C48H62ClN11O8S2
Molecular Weight
1020.66
References & Citations
[1]Roman C Sarott, et al. Relocalizing transcriptional kinases to activate apoptosis. Science. 2024 Oct 4;386 (6717) :eadl5361.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
Available Sizes
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