YM-44778
Product Specifications
UNSPSC Description
YM-44778 is a neurokinin receptor antagonist. The pKi values for NK1, NK2 and NK3 are 8.08, 8.55 and 8.24, respectively. YM-44778 inhibits the increase of bladder pressure induced by substance [Sar9,Met(O2)11] -P (HY-P1012) in anestheticized rats[1].
Target Antigen
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ym-44778.html
Smiles
O=C(C1=CC(OC)=C(C(OC)=C1)OC)N(C)CC(CCN2CCC3(NC(CC4=C3C=CC=C4)=O)CC2)C5=CC=C(C(Cl)=C5)Cl
Molecular Weight
640.60
References & Citations
[1]Choppin A, et al. Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. Pharmacology. 2002;65(2):96-102.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120167/YM-44778-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120167/
Clinical Information
No Development Reported
CAS Number
173941-74-7
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