Danuglipron (tromethamine)

Danuglipron (PF-06882961) tromethamine is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron tromethamine has the potential for type 2 diabetes research[1][2].

Product Specifications

CAS Number

[2230198-03-3]

Product Name Alternative

PF-06882961 (tromethamine)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/danuglipron-tromethamine.html

Solubility

10 mM in DMSO

Smiles

OCC(CO)(N)CO.FC(C=C(C=C1)C#N)=C1COC2=NC(C(CC3)CCN3CC(N(C4=C5)C[C@@H]6CCO6)=NC4=CC=C5C(O)=O)=CC=C2

Molecular Formula

C35H41FN6O7

Molecular Weight

676.73

Precautions

P261-P280-P302+P352

References & Citations

[1]David A Griffithm, et al. A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. J Med Chem. 2022 Jun 23;65 (12) :8208-8226. |[2]W. GUO, et al. Preclinical pharmacology of low molecular weight GLP-1 receptor agonist XW014.