L5-DA
L5-DA is a G-quadruplex (G4) ligand and selectively stabilized for G4s over ds26. L5-DA exhibits significant cytotoxicity against HeLa cells (IC50=4.3 μM) . L5-DA stabilizes G4s in HeLa cells, induces apoptosis, and cell cycle arrest[1].
Product Specifications
CAS Number
2986876-41-7
UNSPSC
12352005
Target
Apoptosis; G-quadruplex
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l5-da.html
Purity
99.03
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CN(CCOC1=CC2=C(N(C=C2)C3=CC=C4C=CC(N5C=CC6=C5C=CC(OCCN(C)C)=C6)=NC4=N3)C=C1)C
Molecular Formula
C32H34N6O2
Molecular Weight
534.65
References & Citations
[1]Wang Y, et al. A naphthyridine-indole ligand for selective stabilization of G-quadruplexes and conformational conversion of hybrid topology. Bioorg Med Chem. 2021;48:116416.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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