Briquilimab Antibody
Briquilimab (JSP-191) is a humanized anti-KIT (CD117) monoclonal antibody that blocks SCF binding, inhibiting KIT signaling and inducing mast cell apoptosis via the Bim pathway. This mechanism supports its research application in mast cell-driven diseases like chronic urticaria and asthma, with studies conducted in both in vitro and in vivo experimental models.
Product Specifications
Product Name Alternative
AMG191, AMG-191, Briquilimab, JSP 191, JSP191, JSP-191
Target
C-Kit
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Signal Transduction
Concentration
6.38 mg/mL
Purity
95.00% (May vary between batches)
Molecular Weight
145.56 KDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
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