CMPD101 (hydrochloride)
CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC50s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC50s =1.4 μM and 8.1 μM, respectively) [1].
Product Specifications
CAS Number
1941168-71-3
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK) ; PKC; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cmpd101-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(NCC2=NN=C(C3=CC=NC=C3)N2C)=CC=C1)NCC4=CC=CC=C4C(F)(F)F.[H]Cl
Molecular Formula
C24H22ClF3N6O
Molecular Weight
502.92
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2; PKCα; ROCK2
Frequently Asked Questions
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