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Minodronic acid-d4

Minodronic acid-d4 is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].

Product Specifications

CAS Number

1807367-80-1

Product Name Alternative

YM-529-d4

UNSPSC

12352005

Target

Apoptosis; Isotope-Labeled Compounds; P2X Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

O=P(O)(O)C(P(O)(O)=O)(O)CC1=CN=C2N1C([2H])=C([2H])C([2H])=C2[2H]

Molecular Formula

C9H8D4N2O7P2

Molecular Weight

326.17

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95 (10) :1354-61.|[3]Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36 (1) :54-63.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

P2X2 Receptor; P2X3 Receptor

Available Sizes

Frequently Asked Questions

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