Lactucin

Lactucin is an anti-inflammatory agent. Lactucin induces cancer cell apoptosis. Lactucin also shows analgesic, anticancer and antimalarial activities[1][2][3][4].

Product Specifications

CAS Number

[1891-29-8]

UNSPSC

12352005

Hazard Statement

H317

Target

Apoptosis; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lactucin.html

Purity

99.72

Solubility

DMSO : ≥ 250 mg/mL

Smiles

OCC([C@]1([H])[C@]2([H])[C@]([C@H](CC(C)=C13)O)([H])C(C(O2)=O)=C)=CC3=O

Molecular Formula

C15H16O5

Molecular Weight

276.28

Precautions

H317

References & Citations

[1]Dang T, et al. Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities. Fitoterapia. 2019 Jul;136:104170.|[2]Gromek D, et al. Biologically active preparations from Lactuca virosa L. Phytotherapy Research, 1992, 6 (5) : 285-287.|[3]Zhang F H, et al. Lactucin induces potent anti-cancer effects in HL-60 human leukemia cancer cells by inducing apoptosis and sub-G1 cell cycle arrest. Bangladesh Journal of Pharmacology, 2016, 11 (2) : 478-484.|[4]Bischoff TA, et al. Antimalarial activity of lactucin and lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L. J Ethnopharmacol. 2004 Dec;95 (2-3) :455-7.