AZD6918
AZD6918 is an orally active and selective Trk tyrosine kinase inhibitor. AZD6918 induces cell death as a single agent and attenuates BDNF/TrkB-induced protection from Etoposide in vitro. AZD6918 can be used for the research of neuroblastoma[1].
Product Specifications
CAS Number
905585-60-6
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd6918.html
Smiles
N#CC1=C(N=C(C(F)=C1)NC2=NNC(OC(C)C)=C2)N[C@@H](C)C3=CC=C(C=C3)F
Molecular Formula
C20H20F2N6O
Molecular Weight
398.41
References & Citations
[1]Li Z, et al. Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. Cancer Biol Ther. 2015;16 (3) :477-83.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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