PPZ-A10
PPZ-A10 is an ionizable cationic lipid. PPZ-A10 preferentially delivers mRNA to liver and spleen immune cells. Pi-LNPs containing PPZ-A10 can effectively deliver mRNA/siRNA to solid tumors[1][2].
Product Specifications
CAS Number
[2941268-67-1]
UNSPSC
12352005
Target
Liposome
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ppz-a10.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(CCN(CCCCCCCCCC)CCCCCCCCCC)NCCCN1CCN(CCCNC(CCN(CCCCCCCCCC)CCCCCCCCCC)=O)CC1
Molecular Formula
C56H114N6O2
Molecular Weight
903.54
References & Citations
[1]Ni H, et al. Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nat Commun. 2022;13 (1) :4766. |[2]Subhan MA, et al. Biopolymer-Based Nanosystems for siRNA Drug Delivery to Solid Tumors including Breast Cancer. Pharmaceutics. 2023 Jan 1;15 (1) :153.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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