CS17919
CS17919 is a potent, selective and orally active ASK1 inhibitor with an IC50 of 22.52 nM. CS17919 shows anti-inflammatory and antifibrotic effects. CS17919 can be used for the study of metabolic-related kidney and liver diseases[1].
Product Specifications
CAS Number
2379346-41-3
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cs17919.html
Smiles
CC1=C(C=C(C(F)=C1)C(NC2=NC(C3=NN=CN3[C@@H](C(F)(F)F)C)=CC=C2)=O)NC(C4CC4)=O
Molecular Formula
C22H20F4N6O2
Molecular Weight
476.43
References & Citations
[1]Guoqiang Liao, et al. Targeting ASK1 by CS17919 alleviates kidney- and liver-related diseases in murine models. Animal Model Exp Med. 2024 Jun 14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1
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