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CS17919

CS17919 is a potent, selective and orally active ASK1 inhibitor with an IC50 of 22.52 nM. CS17919 shows anti-inflammatory and antifibrotic effects. CS17919 can be used for the study of metabolic-related kidney and liver diseases[1].

Product Specifications

CAS Number

2379346-41-3

UNSPSC

12352005

Target

MAP3K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cs17919.html

Smiles

CC1=C(C=C(C(F)=C1)C(NC2=NC(C3=NN=CN3[C@@H](C(F)(F)F)C)=CC=C2)=O)NC(C4CC4)=O

Molecular Formula

C22H20F4N6O2

Molecular Weight

476.43

References & Citations

[1]Guoqiang Liao, et al. Targeting ASK1 by CS17919 alleviates kidney- and liver-related diseases in murine models. Animal Model Exp Med. 2024 Jun 14.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAP3K5/ASK1

Frequently Asked Questions

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