Ambelline

Ambelline is an alkaloid that can be isolated from the Amaryllidaceae family. Ambelline shows antimalarial activity against Dd2 P. falciparum strain, with an IC50 of 7.3 ± 0.3 μM[1][2].

[1]Breiterová KH, et al. Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro. Pharmaceutics. 2023 Mar 21;15(3):1007. |[2]Ritomská A, et al. Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities. Saudi Pharm J. 2023 Aug;31(8):101684.