Retatrutide (TFA)
Product Specifications
UNSPSC Description
Retatrutide (LY3437943) TFA is a triple agonist peptide of the glucagon receptor (GCGR), glucosedependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide TFA binds human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively. Retatrutide TFA can be used for the research of obesity[1].
Target Antigen
GCGR; GLP Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/retatrutide-tfa.html
Purity
99.31
Solubility
DMSO : ≥ 100 mg/mL|H2O : 20 mg/mL (ultrasonic;adjust pH to 9 with NH3·H2O)
Smiles
[Retatrutide (TFA)]
Molecular Weight
4731.33 (free base)
References & Citations
[1]Tamer Coskun, et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P3506A/Retatrutide-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P3506A/Retatrutide-TFA-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
Available Sizes
Curated Selection
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