Encequidar

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

Product Specifications

CAS Number

[849675-66-7]

Product Name Alternative

HM30181; HM30181A

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/HM30181.html

Purity

98.0

Solubility

DMSO : 2.4 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=CC=CC=C2O1)=O)NC3=CC(OC)=C(OC)C=C3C4=NN(C5=CC=C(CCN6CC7=C(C=C(OC)C(OC)=C7)CC6)C=C5)N=N4

Molecular Formula

C38H36N6O7

Molecular Weight

688.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Bauer F, et al. Interaction of HM30181 with P-glycoprotein at the murine blood-brain barrier assessed with positron emission tomography. Eur J Pharmacol. 2012 Dec 5;696 (1-3) :18-27.|[2]Kim TE, et al. Effects of HM30181, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of loperamide in healthy volunteers. Br J Clin Pharmacol. 2014 Sep;78 (3) :556-64.