Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

C25-140

C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity[1].

Product Specifications

CAS Number

1358099-18-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E1/E2/E3 Enzyme; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c25-140.html

Purity

99.92

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(CC2=CC=CC=C2)CC1)CCC3=C(C)N(C4=NN5C(C=C4)=NN=C5C)N=C3C

Molecular Formula

C26H31N7O

Molecular Weight

457.57

Precautions

H302, H315, H319

References & Citations

[1]Brenke JK, et al. Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. J Biol Chem. 2018 Aug 24;293 (34) :13191-13203.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tissue Genomic DNA, Breast
CD563487 5 µg

Tissue Genomic DNA, Breast

Sign In for Pricing
View Details
EIF4G1 pSer1232 Rabbit Polyclonal Antibody
AP08034PU-N 100 µL

EIF4G1 pSer1232 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
DR5 (TNFRSF10B) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1B9]
TA807279BM 100 µL

DR5 (TNFRSF10B) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1B9]

Sign In for Pricing
View Details
ADRM1 (NM_007002) Human Over-expression Lysate
LY402072 100 µg

ADRM1 (NM_007002) Human Over-expression Lysate

Sign In for Pricing
View Details
RANBP9 Rabbit Monoclonal Antibody [Clone ID: 23GB4120]
TA425187 100 µL

RANBP9 Rabbit Monoclonal Antibody [Clone ID: 23GB4120]

Sign In for Pricing
View Details
DDX49 Human Gene Knockout Kit (CRISPR)
KN401053 1 Kit

DDX49 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details