SMU127

SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-κB signaling in cells expressing human TLR2 (EC50=0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

Product Specifications

CAS Number

[903864-87-9]

Product Name Alternative

ZINC666243

UNSPSC

12352005

Target

TNF Receptor; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smu127.html

Smiles

O=C(C1=C(NC(N2CCN(C)CC2)=O)SC3=C1CCC3)OCC

Molecular Formula

C16H23N3O3S

Molecular Weight

337.44

References & Citations

[1]Chen, et al. Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library database. Chem. Commun. (Camb.) 54 (81), 11411-11414 (2018) .