Ac-DEVD-pNA

Ac-DEVD-pNA is a ligand for caspase-3/-7 and related cysteine proteases[1][2].

Product Specifications

CAS Number

[189950-66-1]

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Caspase

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Ac-DEVD-pNA.html

Purity

98.96

Solubility

DMSO : 32.26 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O

Molecular Formula

C26H34N6O13

Molecular Weight

638.58

Precautions

H302, H315, H319

References & Citations

[1]Talanian RV, et al. Substrate specificities of caspase family proteases. J Biol Chem. 1997 Apr 11;272 (15) :9677-82.|[2]Peterson QP, et al. Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis. Nat Protoc. 2010 Feb;5 (2) :294-302.