Cabamiquine

Cabamiquine (DDD107498) is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].

Product Specifications

CAS Number

[1469439-69-7]

Product Name Alternative

DDD107498; DDD-498; M5717

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CaMK; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cabamiquine.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5

Molecular Formula

C27H31FN4O2

Molecular Weight

462.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Baragaña B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522 (7556) :315-20.|[2]Baragaña B, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. J Med Chem. 2016 Nov 10;59 (21) :9672-9685.