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MMH1

Product Specifications

UNSPSC Description

MMH1 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4BD2)[1].

Target Antigen

Epigenetic Reader Domain; Molecular Glues

Type

Reference compound

Related Pathways

Epigenetics;PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmh1.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C)SC2=C1C(C3=CC=C(NC(C=C)=O)C=C3)=N[C@@H](CC(OC(C)(C)C)=O)C4=NN=C(C)N42

Molecular Weight

491.61

References & Citations

[1]Yen-Der Li, et al. Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv. 2023 Feb 15:2023.02.14.528208.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-156827/MMH1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-156827/MMH1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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