Grossamide

Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects[1].

Product Specifications

CAS Number

[80510-06-1]

UNSPSC

12352005

Target

Interleukin Related; MyD88; NF-κB; TNF Receptor; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/grossamide.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1C2=CC(/C=C/C(NCCC(C=C3)=CC=C3O)=O)=CC(OC)=C2O[C@]1([H])C(C=C4)=CC(OC)=C4O)NCCC(C=C5)=CC=C5O

Molecular Formula

C36H36N2O8

Molecular Weight

624.68

References & Citations

[1]Luo Q, et al. Anti-neuroinflammatory effects of grossamide from hemp seed via suppression of TLR-4-mediated NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Mol Cell Biochem. 2017 Apr;428 (1-2) :129-137.