Falcarindiol

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties[1][2]. Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[55297-87-5]

UNSPSC

12352211

Target

Apoptosis; Autophagy; PPAR

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/falcarindiol.html

Purity

99.48

Solubility

DMSO : ≥ 33.33 mg/mL

Smiles

C=C[C@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC

Molecular Formula

C17H24O2

Molecular Weight

260.37

References & Citations

[1]Tingting Lu, et al. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One. 2017 Apr 25;12 (4) :e0176348.|[2]Camilla Bertel Andersen, et al. Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models. Front Pharmacol. 2020 Aug 28;11:565524.