Gartisertib
Gartisertib (VX-803) is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of 50 of 8 nM. Antitumor activity[1][2].
Product Specifications
CAS Number
1613191-99-3
Product Name Alternative
VX-803; M4344; ATR inhibitor 2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-inhibitor-2.html
Purity
99.77
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=C2N=CC(F)=CN2N=C1N)NC3=C(N4CCC(C(N5CCN(C6COC6)CC5)=O)CC4)C(F)=CN=C3
Molecular Formula
C25H29F2N9O3
Molecular Weight
541.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Frank T. Zenke, et al. Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy. Experimental and Molecular Therapeutics.|[2]Gorecki L, et al. Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620) : Clinical candidate for cancer therapy. Pharmacol Ther. 2020 Feb 26:107518.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATR
Available Sizes
Frequently Asked Questions
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