Granuliberin R

Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine[1][2].

Product Specifications

CAS Number

[64704-41-2]

UNSPSC

12352209

Target

Histamine Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/granuliberin-r.html

Solubility

10 mM in DMSO

Smiles

N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](C)C(N[C@@H](CO)C(N)=O)=O)=O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O

Molecular Formula

C69H103N19O14

Molecular Weight

1422.68

References & Citations

[1]Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo) . 1977 Sep;25 (9) :2464-5. |[2]Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo) . 1979 Feb;27 (2) :492-8. |[3]Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15;300 (Pt 1) (Pt 1) :217-27. |[4]Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8 (3) :727-34.