Alimemazine hemitartrate

Alimemazine hemitartrate (Trimeprazine hemitartrate) is an antagonist of the histamine (HA) receptor that can be taken orally and also acts as a partial agonist at other GPCR receptors. Alimemazine hemitartrate has effects that include anti-serotonin, antispasmodic, antihistamine, sedation, hypnotic, antiviral, and anti-nausea properties. Alimemazine hemitartrate promotes the growth of pancreatic β-cells in mice and improves diabetes in mice[1][2][3].

Product Specifications

CAS Number

[4330-99-8]

Product Name Alternative

Trimeprazine hemitartrate

UNSPSC

12352005

Hazard Statement

H301

Target

Histamine Receptor; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Alimemazine_hemitartrate.html

Concentration

10mM

Purity

98.44

Solubility

DMSO : 30 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

CC(CN(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C13.O=C(O)[C@H](O)[C@@H](O)C(O)=O

Molecular Formula

C18H22N2S.1/2C4H6O6

Molecular Weight

373.49

Precautions

H301

References & Citations

[1]Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5 (4) :257-64.|[2]Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1 (3) .|[3]Mei Hashizume, et al. Phenothiazines inhibit SARS-CoV-2 cell entry via a blockade of spike protein binding to neuropilin-1. Antiviral Research. Volume 209, January 2023, 105481