Antibacterial agent 195

Antibacterial agent 195 (compound A20), a Matrine (HY-N0164) derivative, is a potent antibiotic. Antibacterial agent 195 shows antibacterial activity against Gram-positive bacterium (MICS.aureus=0.021 mg/mL; MICP.acnes=0.030 mg/mL), Gram-negative bacterium (MICE.coli=0.092 mg/mL; MICC.albicans=0.379 mg/mL) and Fungus (MIC=2.806 mg/mL) [1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Antibiotic; Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-195.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(C=C(CC3=CC=C(C(F)(F)F)C=C3)C=C2)N1)N4[C@@](CCCC(OC)=O)([H])[C@]5([H])[C@](N6CCC5)([H])[C@](CCC6)([H])C4

Molecular Formula

C33H38F3N3O3

Molecular Weight

581.67

References & Citations

[1]Yufang Li, et al. Synthesis, antibacterial activity, and 3D-QASR studies of matrine-indole derivatives as potential antibiotics. Bioorg Med Chem Lett. 2024 Feb 21:102:129671.